Sotirios works in the area of computational design. He examines the computational processes of design and the association of form, structure, function, and performance in architecture.

As faculty at the School of Architecture of the National Technical University of Athens (NTUA) and a research associate at the Massachusetts Institute of Technology (MIT), Sotirios works on applications of computational design. He teaches Shape Grammars and History and Logic of Design Systems courses, including geometric and topological aspects for form, structure, symmetry, proportion, order, and typology. Sotirios also conducts interdisciplinary research on the applications of networked technologies and Artificial Intelligence in design and architecture at a building and urban scale.

From MIT, Sotirios received his Ph.D. in design and computation and S.M.Arch.S. in design technology. Under a Fulbright Scholarship, he received an M. Arch degree from the Southern California Institute of Architecture (SCI-Arc). He holds a Diploma of Architect-Engineer from NTUA.